Peptides and proteins play crucial roles in every aspect of life. Their chemical synthesis allows for the incorporation of non-canonical amino acids, post-translational modifications, peptide backbone modifications, and functional handles. However, chemical peptide synthesis requires highly efficient transformations to ensure successful incorporation of every single building block.
Continuous-flow synthesis is gaining momentum due to the precise control over reaction parameters and the possibility for automated in-line analytical monitoring. We use flow chemistry to develop efficient reactions and synthesize non-natural building blocks for the production of sequence-defined polymers. We are interested in studying all components of the system - including the development of new technology and biological applications of the synthetic products.
Our goal is to ultimately provide tailored peptidic natural products, proteins and related functional polymers on demand.