Hartrampf Lab | Our Published Work

PUBLISHED WORK

ORCID-ID: 0000-0003-0875-6390

GOOGLE SCHOLAR

‡ = authors contributed equally

* = corresponding author

2026

J. Org. Chem, accepted for publication.

Document

Immobilized Activation Base for Solid-Phase Peptide Synthesis in Flow

– A. Wettler,‡ B. Tamás,‡ N. Hartrampf*

2025

ACS Chem. Biol. 20, 11, 2733–2740

Document

Development of ArgTag for scalable solid-phase synthesis of aggregation peptides

– V. Freiburghaus, A. Jeandin, F. Frankiewicz, J. Yang, N. Hartrampf

2024

Adv. Neural Inf. Process Syst., 37, 125780–125808

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Unraveling Molecular Structure: A Multimodal Spectroscopic Dataset for Chemistry

– M. Alberts*, O. Schilter, F. Zipoli, N. Hartrampf, T. Laino

2024

Chem. Sci., 15, 8756–8765

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Rapid Flow-Based Synthesis of Post-Translationally Modified Peptides and Proteins: A Case Study on MYC’s N-terminus

– E. T. Williams, K. Schiefelbein, M. Schuster, I. M. M. Ahmed, M. De Vries, R. Beveridge, O. Zerbe, N. Hartrampf*

2023

eLife, 12: RP86628

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Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

– L. Duffet,‡ E. T. Williams,‡ A. Gresch, S. Chen, M. A. Bhat, D. Benke, N. Hartrampf,* T. Patriarchi*

2020

Pept. Sci., e24198

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Flow-based SPPS for protein synthesis: A perspective

– Z. P. Gates,* N. Hartrampf*

2026

BioRxiv, https://doi.org/10.64898/2026.04.27.720971

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Phosphorylation tunes electrostatically driven protein-RNA interactions

– M Synakewicz*, A. Premanand, H. Bürgisser, S. Habeler,L. R. Franchini,N. Kociolek, M. Nüesch, A. Clery, D. Nettels, F. Allain, N. Hartrampf,* B. Schuler*

2025

ChemRxiv

Document

Automated Structure Elucidation at Human-Level Accuracy via a Multimodal Multitask Language Model

– M. Alberts,* N. Hartrampf, T. Laino

2024

J. Am. Chem. Soc., 146 (50), 34887– 34899

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A versatile “Synthesis Tag” (SynTag) for the chemical synthesis of aggregating peptides and proteins

– H. Bürgisser,‡ E. T. Williams,‡ A. Jeandin, R. Lescure, A. Premanand, S. Wang, N. Hartrampf*

2024

eLife, 13: RP96496

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Probing PAC1 receptor activation across species with an engineered sensor

– R. B. Cola, S. N. Niethammer, P. Rajamannar, A. Gresch, M. A. Bhat, K. Assoumou, E. T. Williams, P. Hauck, N. Hartrampf, D. Benke, M. Stoeber, G. Levkowitz, S. Melzer, T. Patriarchi*

2022

React. Chem. Eng.

Document

A photocaged orexin-B for spatiotemporally precise control of orexin signaling

– L. Duffet,‡ E. T. Williams,‡ A. Gresch, S. Chen, M. A Bhat, D. Benke, N Hartrampf*, T. Patriarchi*

2026

Nat. Chem., 18, 677–685

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Amino acid composition drives aggregation during peptide synthesis

– B. Tamás,‡ M. Alberts,‡ T. Laino, N. Hartrampf*

2025

Anal. Chem., 97, 15736–1574

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From Spectra to Structure: AI-Powered 31P-NMR Interpretation

– M. Alberts*, N. Hartrampf, T. Laino

2024

J. Am. Chem. Soc., 146 (25), 17261–17269

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Merging Flow Synthesis and Enzymatic Maturation to Expand the Chemical Space of Lasso Peptides

– K. Schiefelbein, J. Lang, M. Schuster, C. E. Grigglestone, R. Striga, L. Bigler, M. C. Schuman, O. Zerbe, Y. Li, N. Hartrampf*

2024

React. Chem. Eng., 9, 825–832

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A robust data analytical method to investigate sequence-dependence in flow-based peptide synthesis

– B. Tamás,‡ P. L. Willi,‡ H. Bürgisser, N. Hartrampf*

2021

CHIMIA, 75, 480–483

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Flow-Based Methods in Chemical Peptide and Protein Synthesis

– K. Schiefelbein, N. Hartrampf *

2015 – 2024

Pept. Sci., e24198

Peer-reviewed publications.

PostDoc, PhD, Undergraduate.

– Z. P. Gates,* N. Hartrampf*

2023

ACS Chem Biol., 18, 3, 518–527

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Rapid Single-Shot Synthesis of the 217 Amino Acid-Long N-Terminal Domain of Pyocin S2

– A. Saebi,‡ J. S. Brown,‡ V. M., Marando, N. Hartrampf, N. M. Chumbler, S. Hanna, M. Poskus; A. Loas, L. L. Kiessling, D. T. Hung, B. L. Pentelute*

2021

Nat. Commun., 12, 4396

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Fully Automated Fast-Flow Synthesis of Antisense Phosphorodiamidate Morpholino Oligomers

– C. Li, A. Callahan, M. Simon, K. Totaro, A. Mijalis, K.-S. Phadke, G. Zhang, N. Hartrampf, C. Schissel, M. Zhou, H. Zong, G. Hanson, A. Loas, N. Pohl, D. Verhoeven, B. Pentelute

2020

ACS Cent. Sci., 6, 2277–2286

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Deep Learning for Prediction and Optimization of Fast-Flow Peptide Synthesis

– S. Mohapatra,‡ N. Hartrampf,‡ M. Poskus, R. Gomez-Bombarelli, B. L. Pentelute*

2020

Chem. Eur. J., 26, 4476-4479

Document

Immune-Modulating Photochromic Galactosyl Ceramides allow for Optical Control of Cytokine Production

– N. Hartrampf, T. Seki, A. Baumann, P. Watson, N. A. Vepřek, B. E. Hetzler, A. Hoffmann-Röder, M. Tsuji, D. Trauner*

2016

Nat. Prod. Rep., 33, 491–522

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Synthetic Approaches towards Alkaloids Bearing α-Tertiary Amines

– A. Hager,‡ N. Vrielink,‡ D. Hager, J. Lefranc, D. Trauner*

2024

Prot. Sci., 33, 5, e4986

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How hydrophobicity, side chains, and salt affect the dimensions of disordered proteins

– M. C. Baxa, X. Lin, C. D. Mukinay, S. Chakravarthy, J. R. Sachleben, S. Antilla, N. Hartrampf, J. A. Riback, I. A. Gagnon, B. L. Pentelute, P. L. Clark, T. R. Sosnick*

2022

Cancers, 14, 2207

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A Tumor-Homing Peptide Platform enhances Drug Solubility, Improves Blood-Brain Barrier Permeability and Targets Glioblastoma

– C.-F. Cho, C. E. Farquhar, C. M. Fadzen, B. Scott, P. Zhuang, N. v. Spreckelsen, A. Loas, N. Hartrampf, B. L. Pentelute, S. E. Lawler*

2021

Adv. Ther., 4, 2000244

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Targeting glioblastoma using a novel peptide specific to a deglycosylated isoform of brevican

– N. v. Spreckelsen, C. M. Fadzen, N. Hartrampf, Y. Ghotmi, J. M. Wolfe, S. Dubey, B. Y. Yang, M. F. Kijewski, S. Wang, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, B. Scott, E. Murrell, F. C. Bononi, L. G. Luyt, M. DiCarli, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler,* C.-F. Cho*

2020

Nat. Commun., 11, 3183

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Ultra-large chemical libraries for the discovery of high-affinity peptide binders

– A. J. Quartararo, Z. P. Gates, B. A. Somsen, N. Hartrampf, X. Ye, A. Shimada, Y. Kajihara, C. Ottmann, B. L. Pentelute*

2018

J. Am. Chem. Soc., 140, 8675-8680

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Total Synthesis of the Norhasubanan Alkaloid Stephadiamine

– N. Hartrampf, N. Winter, G. Pupo, B. Stoltz, D. Trauner*

2015

ChemMedChem, 10, 134–143

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Targeting a Dynamic Protein–Protein Interaction: Fragment Screening against the Malaria Myosin A Motor Complex

– C. H. Douse, N. Vrielink, Z. Wenlin, E. Cota, E. W. Tate*

2023

Biophys. J., 122, 11, 2325–2341

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Structural Diversity of Photoswitchable Sphingolipids for Optodynamic Control of Lipid Raft Microdomains

– N. Hartrampf,‡ S. M. Leitao,‡ N. Winter, H. Toombs-Ruane, J. A. Frank, P. Schwille, D. Trauner,* H. G. Franquelim*

2022

ACS Cent. Sci., 8, 2, 205

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Automated Flow Synthesis of Peptide-PNA Conjugates

– C. Li, A. J. Callahan, K.-S. Phadke, B. Bellaire, C. E. Farquhar, G. Zhang, C. K. Schissel, A. J. Mijalis, N. Hartrampf, A. Loas, D. E. Verhoeven, B. Pentelute*

2021

ACS Chem. Biol., 16, 1, 58–66

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Identification of N-terminally diversified GLP-1R agonists using saturation mutagenesis and chemical design

– C. K. Longwell, S. Hanna, N. Hartrampf, R. A. Parra Sperberg, P.-S. Huang, B. L. Pentelute, J. R. Cochran*

2020

Science, 368, 980–987

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Synthesis of Proteins by Automated Flow Chemistry

– N. Hartrampf, A. Saebi,‡ M. Poskus,‡ Z. P. Gates, A. J. Callahan, A. E. Cowfer, S. Hanna, S. Antilla, C. K. Schissel, A. J. Quartararo, X. Ye, A. J. Mijalis, M. D. Simon, A. Loas, S. Liu, C. Jessen, T. E. Nielsen, B. L. Pentelute*

2018

Nat. Chem. Biol., 14, 764–767

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Light control of L-type Ca2+ channels using a diltiazem photoswitch

– T. Fehrentz, F. M. E. Huber, N. Hartrampf, T. Bruegmann, J. A. Frank, N. H. F. Fine, D. Malan, J. G. Danzl, D. B. Tikhonov, M. Sumser, P. Sasse, D. J. Hodson, B. S. Zhorov, N. Klöcker, D. Trauner*

2019 – 2024

Pept. Sci., e24198

Perspectives & Conference Reports (Independent)

– Z. P. Gates,* N. Hartrampf*

2023

CHIMIA, 77, 877–878

Document

Peptide Therapeutics Forum 2023

– N. Hartrampf*

2022

CHIMIA, 76, 493

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DMCCB Basel Symposium 2022 - Intrinsically Disordered Proteins as Drug Targets

– E. T. Williams, N. Hartrampf*

2024

CHIMIA, 78, 793–794

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The Swiss Summer School on Chemical Biology, Bergün/ Bravuogn, August 25–29, 2024; Part A: Inspiring Science in an Inspiring Environment

– H. P. Lüthi*, D. Gillingham, N. Hartrampf, J.-L. Reymond*

2023

ChemBioChem, e202300258

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Reflections on Navigating a Pandemic: Perspectives from the Chemical Biology Community” (Editorial for the ChemBioTalents special issue)

– A. C. Conibear,* N. Hartrampf*

2021

CHIMIA, 75, 692–694

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The Young Faculty Meeting 2021 - A Focus on Group Management

– J. de Roo,* N. Hartrampf,* L. Merz*

2024

Nachr. Chem., 72, 56–58

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Trendberichte Biochemie: Chemische Proteinsynthese

– N. Hartrampf*

2023

ChemMedChem, 18, e202300014

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An Active Member of the EFMC: The Division of Medicinal Chemistry and Chemical Biology of the Swiss Chemical Society

– Y. P. Auberson,* F. Benfatti, D. Gillingham, N. Hartrampf

2019

Cell Chem. Biol., 26, 1349–1354

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Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16–19 June 2019, Berlin, Germany

– C. Bello, N. Hartrampf, L. J. Walport, A. C. Conibear