Published Work

6. Immune-Modulating Photochromic Galactosyl Ceramides allow for Optical Control of 

    Cytokine Production

3. Light control of L-type Ca2+ channels using a diltiazem photoswitch

1. Targeting a Dynamic Protein–Protein Interaction: Fragment Screening against the

   Malaria Myosin A Motor Complex

PUBLISHED WORK

15. AUTOMATED FAST-FLOW SYNTHESIS OF PEPTIDE NUCLEIC ACID CONJUGATES

C. Li, A. J. Callahan, K.-S. Phadke, B. Bellaire, C. E. Farquhar, G. Zhang, C. K. Schissel, A. J. Mijalis, N. Hartrampf, A. Loas, D. E. Verhoeven, B. Pentelute

Preprint on ChemRxiv (https://doi.org/10.26434/chemrxiv.14099042.v1 link)

14. TARGETING GLIOBLASTOMA USING A NOVEL PEPTIDE SPECIFIC TO A 
      DEGLYCOSYLATED ISOFORM OF BREVICAN

N. v. Spreckelsen, C. M. Fadzen, N. Hartrampf, Y. Ghotmi, J. M. Wolfe, S. Dubey, B. Y. Yang, M. F. Kijewski, S. Wang, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, B. Scott, E. Murrell, F. C. Bononi, L. G. Luyt, M. DiCarli, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho

Adv. Ther. 2021, https://doi.org/10.1002/adtp.202000244 (link)

C. K. Longwell, S. Hanna, N. Hartrampf, R. A. P. Sperberg, P.-S. Huang, B. L. Pentelute, J. R. Cochran

ACS Chem. Bio. 2020, 16, 58–66; ACS Editors' Choice (link)

12. FLOW‐BASED SPPS FOR PROTEIN SYNTHESIS: A PERSPECTIVE

Z. P. Gates, N. Hartrampf

Pep. Sci. 2020, e24198. (link)

11. AUTOMATED FAST-FLOW SYNTHESIS OF ANTISENSE PHOSPHORODIAMIDATE
     MORPHOLINO OLIGOMERS

C. Li, A. J. Callahan, M. D. Simon, K. A. Totaro, A. J. Mijalis, N. Hartrampf, C. K. Schissel. M. Zhou, H. Zong, G. J. Hanson, A. Loas, N. L. B. Pohl. B. L. Pentelute, (‡ = authors contributed equally)

Preprint on ChemRxiv (DOI: 10.26434/chemrxiv.12685886.v1, link)

10. DEEP LEARNING FOR PREDICTION AND OPTIMIZATION OF FAST-FLOW
     PEPTIDE SYNTHESIS

S. Mohapatra, N. Hartrampf,‡ M. Poskus, A. Loas R. Gomez-Bombarelli, B. L. Pentelute (‡ = authors contributed equally)

ACS Cent. Sci. 2020, 6, 12, 2277–2286 (link)

9. ULTRA-LARGE CHEMICAL LIBRARIES FOR THE DISCOVERY OF HIGH-AFFINITY
    PEPTIDE BINDERS

A. J. Quartararo, Z. P. Gates, B. A. Somsen, N. Hartrampf, X. Ye, A. Shimada, Y. Kajihara, C. Ottmann, B. L. Pentelute

Nat. Commun. 2020, 11, 3183 (link)

8. SYNTHESIS OF PROTEINS BY AUTOMATED FLOW CHEMISTRY

N. Hartrampf, A. Saebi,‡ M. Poskus,‡ Z. P. Gates, A. J. Callahan, A. E. Cowfer, S. Hanna, S. Antilla, C. K. Schissel, A. J. Quartararo, X. Ye, A. J. Mijalis, M. D. Simon, A. Loas, S. Liu, C. Jessen, T. E. Nielsen, B. L. Pentelute (‡ = authors contributed equally)

Science 2020, 368, 980-987. (link)

 

Highlighted in a Science Perspective: C. Proulx, Science 2020, 368, 941 (link)

and by MIT News (link), Chemistry World (link), CE&N (link), Science Daily (link), Drug Target Review (link), Phys Org (link), the American Peptide Society (link) and others.

7. BTP-7, A NOVEL PEPTIDE FOR THERAPEUTIC TARGETING OF MALIGNANT  
    BRAIN TUMORS

N. von Spreckelsen, Y. Ghotmi, C. M. Fadzen, J. M. Wolfe, N. Hartrampf, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, E. Murrell, F. C. Bononi, L. G. Luyt, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho. BioRxiv: https://www.biorxiv.org/content/10.1101/2020.05.21.106633v1 (link)

6. IMMUNE-MODULATING PHOTOCHROMIC GALACTOSYL CERAMIDES
   ALLOW FOR OPTICAL CONTROL OF CYTOKINE PRODUCTION
5. PROTEIN CHEMISTRY LOOKING AHEAD: 8TH CHEMICAL PROTEIN
   SYNTHESIS MEETING 16-19 JUNE 2019, BERLIN, GERMANY

C. Bello, N. Hartrampf, L. J. Walport, A. C. Conibear

Cell Chem. Biol. 2019, 26, 1349-1354 (link)

4. TOTAL SYNTHESIS OF THE NORHASUBANAN ALKALOID
   STEPHADIAMINE

N. Hartrampf, N. Winter, G. Pupo, B. Stoltz, D. Trauner

J. Am. Chem. Soc. 2018, 140, 8675-8680 (link)

Highlighted in Synfacts: E. M. Carreira, F. Pultar, Synfacts 2018, 14, 0898 (link)

3. LIGHT CONTROL OF L-TYPE CA2+ CHANNELS USING A DILTIAZEM
   PHOTOSWITCH

T. Fehrentz,  F. M. E. Huber, N. Hartrampf, T. Bruegmann, J. A. Frank, N. H. F. Fine, D. Malan, J. G. Danzl, D. B. Tikhonov, M. Sumser, P. Sasse, D. J. Hodson, B. S. Zhorov, N. Klöcker, D. Trauner Nat. Chem. Biol. 2018, 14, 764–767 (link)

Highlighted in Nature Chemical Biology News & Views: V. Vendrell, Nat. Chem. Bio 2018, 14, 749–750 (link)

2. SYNTHETIC APPROACHES TOWARDS ALKALOIDS BEARING ALPHA-
   TERTIARY AMINES
1. TARGETING A DYNAMIC PROTEIN–PROTEIN INTERACTION:
   FRAGMENT SCREENING AGAINST THE MALARIA MYOSIN A MOTOR
   COMPLEX
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