Hartrampf Lab | Our Published Work

6. Immune-Modulating Photochromic Galactosyl Ceramides allow for Optical Control of

Cytokine Production

N. Hartrampf, T, Seki, A. Baumann, P. Watson, N. Vepcek, B. Hetzler, A. Hoffmann-Röder, M. Tsuji, D. Trauner, Chem. Eur. J. 2019, DOI: 10.1002/chem.201905279.

5. Protein Chemistry Looking Ahead

C. Bello, N. Hartrampf, L. J. Walport, A. C. Conibear, Cell Chem. Biol. 2019, 26, 1349-1354.

4. Total Synthesis of the Norhasubanan Alkaloid Stephadiamine

N. Hartrampf, N. Winter, G. Pupo, B. Stoltz, D. Trauner, J. Am. Chem. Soc. 2018, 140, 8675-8680;

Highlighted in Synfacts: E. M. Carreira, F. Pultar, Synfacts 2018, 14, 0898.

PUBLISHED WORK

ORCID-ID: 0000-0003-0875-6390

INDEPENDENT WORK

18. FLOW-BASED METHODS IN CHEMICAL PEPTIDE AND PROTEIN SYNTHESIS

K. Schiefelbein, N. Hartrampf

CHIMIA 2021, 75, 480–483 (link)

17. THE YOUNG FACULTY MEETING 2021 - A FOCUS ON GROUP MANAGEMENT

J. de Roo, N. Hartrampf, L. Merz

CHIMIA 2021, 75, 692–694. (link)

16. FLOW‐BASED SPPS FOR PROTEIN SYNTHESIS: A PERSPECTIVE

Z. P. Gates, N. Hartrampf

Pep. Sci. 2020, e24198. (link)

POSTDOC, PHD and UNDERGRADUATE WORK

15. AUTOMATED FLOW SYNTHESIS OF PEPTIDE–PNA CONJUGATES

C. Li, A. J. Callahan, K.-S. Phadke, B. Bellaire, C. E. Farquhar, G. Zhang, C. K. Schissel, A. J. Mijalis, N. Hartrampf, A. Loas, D. E. Verhoeven, B. Pentelute

ACS Cent. Sci. 2021, https://doi.org/10.1021/acscentsci.1c01019 (link)

14. STRUCTURAL DIVERSITY OF PHOTOSWITCHABLE SPHINGOLIPIDS FOR
OPTODYNAMIC CONTROL OF LIPID RAFT MICRODOMAINS

N. Hartrampf,‡ S. M. Leitao,‡ N. Winter, H. Toombs-Ruane, J. A Frank, P. Schwille, D. Trauner, H. G. Franquelim (‡ = authors contributed equally)

Preprint on BioRxiv (https://doi.org/10.1101/2021.10.11.463883 link)

Screenshot%202020-07-22%20at%2011.39_edi

13. AUTOMATED FAST-FLOW SYNTHESIS OF ANTISENSE PHOSPHORODIAMIDATE
MORPHOLINO OLIGOMERS

C. Li, A. Callahan, M. Simon, K. Totaro, A. Mijalis, K.-S. Phadke, G. Zhang, N. Hartrampf, C. Schissel, M. Zhou, H. Zong, G. Hanson, A. Loas, N. Pohl, D. Verhoeven, B. Pentelute

Nat. Commun. 2021, 12, 4396 (link)

12. TARGETING GLIOBLASTOMA USING A NOVEL PEPTIDE SPECIFIC TO A
DEGLYCOSYLATED ISOFORM OF BREVICAN

N. v. Spreckelsen, C. M. Fadzen, N. Hartrampf, Y. Ghotmi, J. M. Wolfe, S. Dubey, B. Y. Yang, M. F. Kijewski, S. Wang, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, B. Scott, E. Murrell, F. C. Bononi, L. G. Luyt, M. DiCarli, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho

Adv. Ther. 2021, 4, 2000244 (link)

11. IDENTIFICATION OF N-TERMINALLY DIVERSIFIED GLP-1R AGONISTS
USING SATURATION MUTAGENESIS AND CHEMICAL DESIGN

C. K. Longwell, S. Hanna, N. Hartrampf, R. A. P. Sperberg, P.-S. Huang, B. L. Pentelute, J. R. Cochran

ACS Chem. Bio. 2021, 16, 58–66; ACS Editors' Choice (link)

10. DEEP LEARNING FOR PREDICTION AND OPTIMIZATION OF FAST-FLOW

PEPTIDE SYNTHESIS

S. Mohapatra ,‡ N. Hartrampf,‡ M. Poskus, A. Loas R. Gomez-Bombarelli, B. L. Pentelute (‡ = authors contributed equally)

ACS Cent. Sci. 2020, 6, 12, 2277–2286 (link)

9. ULTRA-LARGE CHEMICAL LIBRARIES FOR THE DISCOVERY OF HIGH-AFFINITY

PEPTIDE BINDERS

A. J. Quartararo, Z. P. Gates, B. A. Somsen, N. Hartrampf, X. Ye, A. Shimada, Y. Kajihara, C. Ottmann, B. L. Pentelute

Nat. Commun. 2020, 11, 3183 (link)

8. SYNTHESIS OF PROTEINS BY AUTOMATED FLOW CHEMISTRY

N. Hartrampf, A. Saebi,‡ M. Poskus,‡ Z. P. Gates, A. J. Callahan, A. E. Cowfer, S. Hanna, S. Antilla, C. K. Schissel, A. J. Quartararo, X. Ye, A. J. Mijalis, M. D. Simon, A. Loas, S. Liu, C. Jessen, T. E. Nielsen, B. L. Pentelute (‡ = authors contributed equally)

Science 2020, 368, 980-987. (link)

Highlighted in a Science Perspective: C. Proulx, Science 2020, 368, 941 (link)

and by MIT News (link), Chemistry World (link), CE&N (link), Science Daily (link), Drug Target Review (link), Phys Org (link), the American Peptide Society (link) and others.

7. BTP-7, A NOVEL PEPTIDE FOR THERAPEUTIC TARGETING OF MALIGNANT

BRAIN TUMORS

N. von Spreckelsen, Y. Ghotmi, C. M. Fadzen, J. M. Wolfe, N. Hartrampf, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, E. Murrell, F. C. Bononi, L. G. Luyt, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho. BioRxiv: https://www.biorxiv.org/content/10.1101/2020.05.21.106633v1 (link)

6. IMMUNE-MODULATING PHOTOCHROMIC GALACTOSYL CERAMIDES

ALLOW FOR OPTICAL CONTROL OF CYTOKINE PRODUCTION

N. Hartrampf, T, Seki, A. Baumann, P. Watson, N. A. Veprek, B. Hetzler, A. Hoffmann-Röder, M. Tsuji, D. Trauner

Chem. Eur. J. 2020, 20, 4476 (link)

5. PROTEIN CHEMISTRY LOOKING AHEAD: 8TH CHEMICAL PROTEIN

SYNTHESIS MEETING 16-19 JUNE 2019, BERLIN, GERMANY

C. Bello, N. Hartrampf, L. J. Walport, A. C. Conibear

Cell Chem. Biol. 2019, 26, 1349-1354 (link)

4. TOTAL SYNTHESIS OF THE NORHASUBANAN ALKALOID

STEPHADIAMINE

N. Hartrampf, N. Winter, G. Pupo, B. Stoltz, D. Trauner

J. Am. Chem. Soc. 2018, 140, 8675-8680 (link)

Highlighted in Synfacts: E. M. Carreira, F. Pultar, Synfacts 2018, 14, 0898 (link)

3. LIGHT CONTROL OF L-TYPE CA2+ CHANNELS USING A DILTIAZEM

PHOTOSWITCH

T. Fehrentz, F. M. E. Huber, N. Hartrampf, T. Bruegmann, J. A. Frank, N. H. F. Fine, D. Malan, J. G. Danzl, D. B. Tikhonov, M. Sumser, P. Sasse, D. J. Hodson, B. S. Zhorov, N. Klöcker, D. Trauner Nat. Chem. Biol. 2018, 14, 764–767 (link)

Highlighted in Nature Chemical Biology News & Views: V. Vendrell, Nat. Chem. Bio 2018, 14, 749–750 (link)

2. SYNTHETIC APPROACHES TOWARDS ALKALOIDS BEARING ALPHA-

TERTIARY AMINES

A. Hager,‡ N. Vrielink, ‡ D. Hager, J. Lefranc, D. Trauner (‡ = authors contributed equally)

Nat. Prod. Rep. 2016, 33, 491–522 (link)

6. Immune-Modulating Photochromic Galactosyl Ceramides allow for Optical Control of

Cytokine Production

5. Protein Chemistry Looking Ahead

4. Total Synthesis of the Norhasubanan Alkaloid Stephadiamine

18. FLOW-BASED METHODS IN CHEMICAL PEPTIDE AND PROTEIN SYNTHESIS

17. THE YOUNG FACULTY MEETING 2021 - A FOCUS ON GROUP MANAGEMENT

16. FLOW‐BASED SPPS FOR PROTEIN SYNTHESIS: A PERSPECTIVE

15. AUTOMATED FLOW SYNTHESIS OF PEPTIDE–PNA CONJUGATES

14. STRUCTURAL DIVERSITY OF PHOTOSWITCHABLE SPHINGOLIPIDS FOR
OPTODYNAMIC CONTROL OF LIPID RAFT MICRODOMAINS

13. AUTOMATED FAST-FLOW SYNTHESIS OF ANTISENSE PHOSPHORODIAMIDATE
MORPHOLINO OLIGOMERS

12. TARGETING GLIOBLASTOMA USING A NOVEL PEPTIDE SPECIFIC TO A
DEGLYCOSYLATED ISOFORM OF BREVICAN

11. IDENTIFICATION OF N-TERMINALLY DIVERSIFIED GLP-1R AGONISTS
USING SATURATION MUTAGENESIS AND CHEMICAL DESIGN

10. DEEP LEARNING FOR PREDICTION AND OPTIMIZATION OF FAST-FLOW

PEPTIDE SYNTHESIS

9. ULTRA-LARGE CHEMICAL LIBRARIES FOR THE DISCOVERY OF HIGH-AFFINITY

PEPTIDE BINDERS

8. SYNTHESIS OF PROTEINS BY AUTOMATED FLOW CHEMISTRY

7. BTP-7, A NOVEL PEPTIDE FOR THERAPEUTIC TARGETING OF MALIGNANT

BRAIN TUMORS

6. IMMUNE-MODULATING PHOTOCHROMIC GALACTOSYL CERAMIDES

ALLOW FOR OPTICAL CONTROL OF CYTOKINE PRODUCTION

5. PROTEIN CHEMISTRY LOOKING AHEAD: 8TH CHEMICAL PROTEIN

SYNTHESIS MEETING 16-19 JUNE 2019, BERLIN, GERMANY

4. TOTAL SYNTHESIS OF THE NORHASUBANAN ALKALOID

STEPHADIAMINE

3. LIGHT CONTROL OF L-TYPE CA2+ CHANNELS USING A DILTIAZEM

PHOTOSWITCH

2. SYNTHETIC APPROACHES TOWARDS ALKALOIDS BEARING ALPHA-

TERTIARY AMINES

1. TARGETING A DYNAMIC PROTEIN–PROTEIN INTERACTION:

FRAGMENT SCREENING AGAINST THE MALARIA MYOSIN A MOTOR

COMPLEX

6. Immune-Modulating Photochromic Galactosyl Ceramides allow for Optical Control of

Cytokine Production

5. Protein Chemistry Looking Ahead

4. Total Synthesis of the Norhasubanan Alkaloid Stephadiamine

18. FLOW-BASED METHODS IN CHEMICAL PEPTIDE AND PROTEIN SYNTHESIS

17. THE YOUNG FACULTY MEETING 2021 - A FOCUS ON GROUP MANAGEMENT

16. FLOW‐BASED SPPS FOR PROTEIN SYNTHESIS: A PERSPECTIVE

15. AUTOMATED FLOW SYNTHESIS OF PEPTIDE–PNA CONJUGATES

14. STRUCTURAL DIVERSITY OF PHOTOSWITCHABLE SPHINGOLIPIDS FOR OPTODYNAMIC CONTROL OF LIPID RAFT MICRODOMAINS

13. AUTOMATED FAST-FLOW SYNTHESIS OF ANTISENSE PHOSPHORODIAMIDATE MORPHOLINO OLIGOMERS

12. TARGETING GLIOBLASTOMA USING A NOVEL PEPTIDE SPECIFIC TO A DEGLYCOSYLATED ISOFORM OF BREVICAN

11. IDENTIFICATION OF N-TERMINALLY DIVERSIFIED GLP-1R AGONISTS USING SATURATION MUTAGENESIS AND CHEMICAL DESIGN

10. DEEP LEARNING FOR PREDICTION AND OPTIMIZATION OF FAST-FLOW

PEPTIDE SYNTHESIS

9. ULTRA-LARGE CHEMICAL LIBRARIES FOR THE DISCOVERY OF HIGH-AFFINITY

PEPTIDE BINDERS

8. SYNTHESIS OF PROTEINS BY AUTOMATED FLOW CHEMISTRY

7. BTP-7, A NOVEL PEPTIDE FOR THERAPEUTIC TARGETING OF MALIGNANT

BRAIN TUMORS

6. IMMUNE-MODULATING PHOTOCHROMIC GALACTOSYL CERAMIDES

ALLOW FOR OPTICAL CONTROL OF CYTOKINE PRODUCTION

5. PROTEIN CHEMISTRY LOOKING AHEAD: 8TH CHEMICAL PROTEIN

SYNTHESIS MEETING 16-19 JUNE 2019, BERLIN, GERMANY

4. TOTAL SYNTHESIS OF THE NORHASUBANAN ALKALOID

STEPHADIAMINE

3. LIGHT CONTROL OF L-TYPE CA2+ CHANNELS USING A DILTIAZEM

PHOTOSWITCH

2. SYNTHETIC APPROACHES TOWARDS ALKALOIDS BEARING ALPHA-

TERTIARY AMINES

1. TARGETING A DYNAMIC PROTEIN–PROTEIN INTERACTION:

FRAGMENT SCREENING AGAINST THE MALARIA MYOSIN A MOTOR

COMPLEX

14. STRUCTURAL DIVERSITY OF PHOTOSWITCHABLE SPHINGOLIPIDS FOR
OPTODYNAMIC CONTROL OF LIPID RAFT MICRODOMAINS

13. AUTOMATED FAST-FLOW SYNTHESIS OF ANTISENSE PHOSPHORODIAMIDATE
MORPHOLINO OLIGOMERS

12. TARGETING GLIOBLASTOMA USING A NOVEL PEPTIDE SPECIFIC TO A
DEGLYCOSYLATED ISOFORM OF BREVICAN

11. IDENTIFICATION OF N-TERMINALLY DIVERSIFIED GLP-1R AGONISTS
USING SATURATION MUTAGENESIS AND CHEMICAL DESIGN