PUBLISHED WORK
ORCID-ID: 0000-0003-0875-6390
A VERSATILE “SYNTHESIS TAG” (SYNTAG) FOR THE CHEMICAL SYNTHESIS OF AGGREGATING PEPTIDES AND PROTEINS
5. Protein Chemistry Looking Ahead
4. Total Synthesis of the Norhasubanan Alkaloid Stephadiamine
AMINO ACID COMPOSITION DRIVES PEPTIDE AGGREGATION: PREDICTING AGGREGATION FOR IMPROVED SYNTHESIS
B. Tamás,‡ M. Alberts,‡ T. Laino N. Hartrampf* (‡ = authors contributed equally)
ChemRxiv 2024, DOI: 10.26434/chemrxiv-2025-wjbmv
A VERSATILE “SYNTHESIS TAG” (SYNTAG) FOR THE CHEMICAL SYNTHESIS OF AGGREGATING PEPTIDES AND PROTEINS
H. Bürgisser,‡ E. T. Williams,‡ A. Jeandin, R. Lescure, A. Premanand, S. Wang, N. Hartrampf* (‡ = authors contributed equally)
J. Am. Chem. Soc. 2024, 146 (50), 34887–34899.
UNRAVELING MOLECULAR STRUCTURE: A MULTIMODAL SPECTROSCOPIC DATASET FOR CHEMISTRY
M. Alberts*, O. Schilter, F. Zipoli, N. Hartrampf, T. Laino
arXiv 2024, DOI: https://doi.org/10.48550/arXiv.2407.17492.
MERGING FLOW SYNTHESIS AND ENZYMATIC MATURATION TO EXPAND THE CHEMICAL SPACE OF LASSO PEPTIDES
K. Schiefelbein, J. Lang, M. Schuster, C. E. Grigglestone, R. Striga, L. Bigler, M. C. Schuman, O. Zerbe, Y. Li, N. Hartrampf*
J. Am. Chem. Soc. 2024, 146 (25), 17261–17269 (link)
RAPID FLOW-BASED SYNTHESIS OF POST-TRANSLATIONALLY MODIFIED PEPTIDES AND PROTEINS: A CASE STUDY ON MYC’S TRANSACTIVATION DOMAIN
E. T. Williams, K. Schiefelbein, M. Schuster, I. M. M. Ahmed, M. De Vries, R. Beveridge, O. Zerbe, N. Hartrampf*
Chem. Sci. 2024, 15, 8756-8765 (link)
PROBING PAC1 RECEPTOR ACTIVATION ACROSS SPECIES WITH AN ENGINEERED SENSOR
R. B. Cola, S. N. Niethammer, P. Rajamannar, A. Gresch, M. A. Bhat, K. Assoumou, E. T. Williams, P. Hauck, N. Hartrampf, D. Benke, M. Stoeber, G. Levkowitz, S. Melzer, T. Patriarchi
eLife 2024, 13:RP96496 (link)
A ROBUST DATA ANALYTICAL METHOD TO INVESTIGATE SEQUENCE DEPENDENCE IN FLOW-BASED PEPTIDE SYNTHESIS
B. Tamás,‡ P. L. Willi,‡ H. Bürgisser, N. Hartrampf* (‡ = authors contributed equally)
React. Chem. Eng. 2024, 9, 825-832 (link)
OPTICAL TOOLS FOR VISUALIZING AND CONTROLLING HUMAN GLP-1 RECEPTOR ACTIVATION WITH HIGH SPATIOTEMPORAL RESOLUTION
L. Duffet,‡ E. T. Williams,‡ A. Gresch, S. Chen, M. A Bhat, D. Benke, N Hartrampf*, T. Patriarchi* (‡ = authors contributed equally)
elife 2023, 12, RP86628 (link)
A PHOTOCAGED OREXIN-B FOR SPATIOTEMPORALLY PRECISE CONTROL OF OREXIN SIGNALING
L. Duffet,‡ P. V. Tatarskiy,‡ M. Harada,‡ E. T. Williams, N Hartrampf*, T. Patriarchi* (‡ = authors contributed equally)
Cell Chem. Bio. 2022, 29, 1-10 (link)
FLOW-BASED METHODS IN CHEMICAL PEPTIDE AND PROTEIN SYNTHESIS
K. Schiefelbein, N. Hartrampf
CHIMIA 2021, 75, 480–483 (link)
FLOW‐BASED SPPS FOR PROTEIN SYNTHESIS: A PERSPECTIVE
Z. P. Gates, N. Hartrampf
Pep. Sci. 2020, e24198. (link)
PRIOR TO UZH (PostDoc, Ph.D., Undergrad)
STRUCTURAL DIVERSITY OF PHOTOSWITCHABLE SPHINGOLIPIDS FOR
OPTODYNAMIC CONTROL OF LIPID RAFT MICRODOMAINS
N. Hartrampf,‡ S. M. Leitao,‡ N. Winter, H. Toombs-Ruane, J. A Frank, P. Schwille, D. Trauner, H. G. Franquelim (‡ = authors contributed equally)
Biophys. J. 2023, 122, 11, 2325-2341 (link)
RAPID SINGLE-SHOT SYNTHESIS OF THE 217 AMINO ACID-LONG N-TERMINAL DOMAIN OF PYOCIN S2
A. Saebi,‡ J. S. Brown,‡ V. M. Marando, N. Hartrampf, N. M. Chumbler, S. Hanna, M. Poskus, A. Loas, L. L. Kiessling, D. T. Hung, B. L. Pentelute (‡ = authors contributed equally)
ACS Chem. Bio. 2023, 18, 3, 518–527 (link)
A TUMOR-HOMING PEPTIDE PLATFORM ENHANCES DRUG SOLUBILITY, IM-
PROVES BLOOD–BRAIN BARRIER PERMEABILITY AND TARGETS GLIOBLASTOMA
C.-F. Cho, C. E. Farquhar, C. M. Fadzen, B. Scott, P. Zhuang, N. v. Spreckelsen, A. Loas, N. Hartrampf, B. L. Pentelute, S. E. Lawler
Cancers 2022, 14, 2207 (link)
AUTOMATED FLOW SYNTHESIS OF PEPTIDE–PNA CONJUGATES
C. Li, A. J. Callahan, K.-S. Phadke, B. Bellaire, C. E. Farquhar, G. Zhang, C. K. Schissel, A. J. Mijalis, N. Hartrampf, A. Loas, D. E. Verhoeven, B. Pentelute
ACS Cent. Sci. 2021, https://doi.org/10.1021/acscentsci.1c01019 (link)
AUTOMATED FAST-FLOW SYNTHESIS OF ANTISENSE PHOSPHORODIAMIDATE
MORPHOLINO OLIGOMERS
C. Li, A. Callahan, M. Simon, K. Totaro, A. Mijalis, K.-S. Phadke, G. Zhang, N. Hartrampf, C. Schissel, M. Zhou, H. Zong, G. Hanson, A. Loas, N. Pohl, D. Verhoeven, B. Pentelute
Nat. Commun. 2021, 12, 4396 (link)
TARGETING GLIOBLASTOMA USING A NOVEL PEPTIDE SPECIFIC TO A
DEGLYCOSYLATED ISOFORM OF BREVICAN
N. v. Spreckelsen, C. M. Fadzen, N. Hartrampf, Y. Ghotmi, J. M. Wolfe, S. Dubey, B. Y. Yang, M. F. Kijewski, S. Wang, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, B. Scott, E. Murrell, F. C. Bononi, L. G. Luyt, M. DiCarli, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho
Adv. Ther. 2021, 4, 2000244 (link)
IDENTIFICATION OF N-TERMINALLY DIVERSIFIED GLP-1R AGONISTS
USING SATURATION MUTAGENESIS AND CHEMICAL DESIGN
C. K. Longwell, S. Hanna, N. Hartrampf, R. A. P. Sperberg, P.-S. Huang, B. L. Pentelute, J. R. Cochran
ACS Chem. Bio. 2021, 16, 58–66; ACS Editors' Choice (link)
DEEP LEARNING FOR PREDICTION AND OPTIMIZATION OF FAST-FLOW
PEPTIDE SYNTHESIS
S. Mohapatra,‡ N. Hartrampf,‡ M. Poskus, A. Loas R. Gomez-Bombarelli, B. L. Pentelute (‡ = authors contributed equally)
ACS Cent. Sci. 2020, 6, 12, 2277–2286 (link)
ULTRA-LARGE CHEMICAL LIBRARIES FOR THE DISCOVERY OF HIGH-AFFINITY
PEPTIDE BINDERS
A. J. Quartararo, Z. P. Gates, B. A. Somsen, N. Hartrampf, X. Ye, A. Shimada, Y. Kajihara, C. Ottmann, B. L. Pentelute
Nat. Commun. 2020, 11, 3183 (link)
SYNTHESIS OF PROTEINS BY AUTOMATED FLOW CHEMISTRY
N. Hartrampf, A. Saebi,‡ M. Poskus,‡ Z. P. Gates, A. J. Callahan, A. E. Cowfer, S. Hanna, S. Antilla, C. K. Schissel, A. J. Quartararo, X. Ye, A. J. Mijalis, M. D. Simon, A. Loas, S. Liu, C. Jessen, T. E. Nielsen, B. L. Pentelute (‡ = authors contributed equally)
Science 2020, 368, 980-987. (link)
Highlighted in a Science Perspective: C. Proulx, Science 2020, 368, 941 (link)
and by MIT News (link), Chemistry World (link), CE&N (link), Science Daily (link), Drug Target Review (link), Phys Org (link), the American Peptide Society (link) and others.
BTP-7, A NOVEL PEPTIDE FOR THERAPEUTIC TARGETING OF MALIGNANT BRAIN TUMORS
N. von Spreckelsen, Y. Ghotmi, C. M. Fadzen, J. M. Wolfe, N. Hartrampf, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, E. Murrell, F. C. Bononi, L. G. Luyt, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho. BioRxiv: https://www.biorxiv.org/content/10.1101/2020.05.21.106633v1 (link)
IMMUNE-MODULATING PHOTOCHROMIC GALACTOSYL CERAMIDES
ALLOW FOR OPTICAL CONTROL OF CYTOKINE PRODUCTION
Chem. Eur. J. 2020, 20, 4476 (link)
PROTEIN CHEMISTRY LOOKING AHEAD: 8TH CHEMICAL PROTEIN
SYNTHESIS MEETING 16-19 JUNE 2019, BERLIN, GERMANY
C. Bello, N. Hartrampf, L. J. Walport, A. C. Conibear
Cell Chem. Biol. 2019, 26, 1349-1354 (link)
TOTAL SYNTHESIS OF THE NORHASUBANAN ALKALOID
STEPHADIAMINE
N. Hartrampf, N. Winter, G. Pupo, B. Stoltz, D. Trauner
J. Am. Chem. Soc. 2018, 140, 8675-8680 (link)
Highlighted in Synfacts: E. M. Carreira, F. Pultar, Synfacts 2018, 14, 0898 (link)
LIGHT CONTROL OF L-TYPE CA2+ CHANNELS USING A DILTIAZEM
PHOTOSWITCH
T. Fehrentz, F. M. E. Huber, N. Hartrampf, T. Bruegmann, J. A. Frank, N. H. F. Fine, D. Malan, J. G. Danzl, D. B. Tikhonov, M. Sumser, P. Sasse, D. J. Hodson, B. S. Zhorov, N. Klöcker, D. Trauner Nat. Chem. Biol. 2018, 14, 764–767 (link)
Highlighted in Nature Chemical Biology News & Views: V. Vendrell, Nat. Chem. Bio 2018, 14, 749–750 (link)
SYNTHETIC APPROACHES TOWARDS ALKALOIDS BEARING ALPHA-
TERTIARY AMINES
A. Hager,‡ N. Vrielink, ‡ D. Hager, J. Lefranc, D. Trauner (‡ = authors contributed equally)
Nat. Prod. Rep. 2016, 33, 491–522 (link)
TARGETING A DYNAMIC PROTEIN–PROTEIN INTERACTION:
FRAGMENT SCREENING AGAINST THE MALARIA MYOSIN A MOTOR
COMPLEX
C. H. Douse, N. Vrielink, Z. Wenlin, E. Cota, E. W. Tate
ChemMedChem 2015, 10, 134–143 (link)