PUBLISHED WORK

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A TUMOR-HOMING PEPTIDE PLATFORM ENHANCES DRUG SOLUBILITY, IM-
PROVES BLOOD–BRAIN BARRIER PERMEABILITY AND TARGETS GLIOBLASTOMA

C.-F. Cho, C. E. Farquhar, C. M. Fadzen, B. Scott, P. Zhuang, N. v. Spreckelsen, A. Loas, N. Hartrampf, B. L. Pentelute, S. E. Lawler

Cancers 2022, 14, 2207 (link)

DMCCB BASEL SYMPOSIUM 2022 - INTRINSICALLY DISORDERED PROTEINS AS DRUG TARGETS

E. T. Williams, N. Hartrampf

CHIMIA 2022, 76, 493. (link)

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FLOW-BASED METHODS IN CHEMICAL PEPTIDE AND PROTEIN SYNTHESIS

K. Schiefelbein, N. Hartrampf

CHIMIA 2021, 75, 480–483 (link)

THE YOUNG FACULTY MEETING 2021 - A FOCUS ON GROUP MANAGEMENT

J. de RooN. HartrampfL. Merz

CHIMIA 2021, 75, 692–694. (link)

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AUTOMATED FLOW SYNTHESIS OF PEPTIDE–PNA CONJUGATES

C. Li, A. J. Callahan, K.-S. Phadke, B. Bellaire, C. E. Farquhar, G. Zhang, C. K. Schissel, A. J. Mijalis, N. Hartrampf, A. Loas, D. E. Verhoeven, B. Pentelute

ACS Cent. Sci. 2021, https://doi.org/10.1021/acscentsci.1c01019 (link)

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STRUCTURAL DIVERSITY OF PHOTOSWITCHABLE SPHINGOLIPIDS FOR
OPTODYNAMIC CONTROL OF LIPID RAFT MICRODOMAINS

N. Hartrampf, S. M. Leitao, N. Winter, H. Toombs-Ruane, J. A Frank, P. Schwille, D. Trauner, H. G. Franquelim (‡ = authors contributed equally)

Preprint on BioRxiv (https://doi.org/10.1101/2021.10.11.463883 link)

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AUTOMATED FAST-FLOW SYNTHESIS OF ANTISENSE PHOSPHORODIAMIDATE
MORPHOLINO OLIGOMERS

C. Li, A. Callahan, M. Simon, K. Totaro, A. Mijalis, K.-S. Phadke, G. Zhang, N. Hartrampf, C. Schissel, M. Zhou, H. Zong, G. Hanson, A. Loas, N. Pohl, D. Verhoeven, B. Pentelute

Nat. Commun. 2021, 12, 4396 (link)

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TARGETING GLIOBLASTOMA USING A NOVEL PEPTIDE SPECIFIC TO A 
DEGLYCOSYLATED ISOFORM OF BREVICAN

N. v. Spreckelsen, C. M. Fadzen, N. Hartrampf, Y. Ghotmi, J. M. Wolfe, S. Dubey, B. Y. Yang, M. F. Kijewski, S. Wang, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, B. Scott, E. Murrell, F. C. Bononi, L. G. Luyt, M. DiCarli, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho

Adv. Ther. 2021, 4, 2000244 (link)

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C. K. Longwell, S. Hanna, N. Hartrampf, R. A. P. Sperberg, P.-S. Huang, B. L. Pentelute, J. R. Cochran

ACS Chem. Bio. 2021, 16, 58–66; ACS Editors' Choice (link)

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FLOW‐BASED SPPS FOR PROTEIN SYNTHESIS: A PERSPECTIVE

Z. P. Gates, N. Hartrampf

Pep. Sci. 2020, e24198. (link)

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DEEP LEARNING FOR PREDICTION AND OPTIMIZATION OF FAST-FLOW
PEPTIDE SYNTHESIS

S. Mohapatra, N. Hartrampf,‡ M. Poskus, A. Loas R. Gomez-Bombarelli, B. L. Pentelute (‡ = authors contributed equally)

ACS Cent. Sci. 2020, 6, 12, 2277–2286 (link)

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ULTRA-LARGE CHEMICAL LIBRARIES FOR THE DISCOVERY OF HIGH-AFFINITY
PEPTIDE BINDERS

A. J. Quartararo, Z. P. Gates, B. A. Somsen, N. Hartrampf, X. Ye, A. Shimada, Y. Kajihara, C. Ottmann, B. L. Pentelute

Nat. Commun. 2020, 11, 3183 (link)

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SYNTHESIS OF PROTEINS BY AUTOMATED FLOW CHEMISTRY

N. Hartrampf, A. Saebi,‡ M. Poskus,‡ Z. P. Gates, A. J. Callahan, A. E. Cowfer, S. Hanna, S. Antilla, C. K. Schissel, A. J. Quartararo, X. Ye, A. J. Mijalis, M. D. Simon, A. Loas, S. Liu, C. Jessen, T. E. Nielsen, B. L. Pentelute (‡ = authors contributed equally)

Science 2020, 368, 980-987. (link)

 

Highlighted in a Science Perspective: C. Proulx, Science 2020, 368, 941 (link)

and by MIT News (link), Chemistry World (link), CE&N (link), Science Daily (link), Drug Target Review (link), Phys Org (link), the American Peptide Society (link) and others.

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BTP-7, A NOVEL PEPTIDE FOR THERAPEUTIC TARGETING OF MALIGNANT  BRAIN TUMORS

N. von Spreckelsen, Y. Ghotmi, C. M. Fadzen, J. M. Wolfe, N. Hartrampf, C. Farquhar, S. Bergmann, M. Zdioruk, J. R. Wasserburg, E. Murrell, F. C. Bononi, L. G. Luyt, M. L. M. Lamfers, K. L. Ligon, E. A. Chiocca, M. S. Viapiano, B. L. Pentelute, S. E. Lawler, C.-F. Cho. BioRxiv: https://www.biorxiv.org/content/10.1101/2020.05.21.106633v1 (link)

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IMMUNE-MODULATING PHOTOCHROMIC GALACTOSYL CERAMIDES
ALLOW FOR OPTICAL CONTROL OF CYTOKINE PRODUCTION
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PROTEIN CHEMISTRY LOOKING AHEAD: 8TH CHEMICAL PROTEIN
SYNTHESIS MEETING 16-19 JUNE 2019, BERLIN, GERMANY

C. Bello, N. Hartrampf, L. J. Walport, A. C. Conibear

Cell Chem. Biol. 2019, 26, 1349-1354 (link)

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TOTAL SYNTHESIS OF THE NORHASUBANAN ALKALOID
STEPHADIAMINE

N. Hartrampf, N. Winter, G. Pupo, B. Stoltz, D. Trauner

J. Am. Chem. Soc. 2018, 140, 8675-8680 (link)

Highlighted in Synfacts: E. M. Carreira, F. Pultar, Synfacts 2018, 14, 0898 (link)

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LIGHT CONTROL OF L-TYPE CA2+ CHANNELS USING A DILTIAZEM
PHOTOSWITCH

T. Fehrentz,  F. M. E. Huber, N. Hartrampf, T. Bruegmann, J. A. Frank, N. H. F. Fine, D. Malan, J. G. Danzl, D. B. Tikhonov, M. Sumser, P. Sasse, D. J. Hodson, B. S. Zhorov, N. Klöcker, D. Trauner Nat. Chem. Biol. 2018, 14, 764–767 (link)

Highlighted in Nature Chemical Biology News & Views: V. Vendrell, Nat. Chem. Bio 2018, 14, 749–750 (link)

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SYNTHETIC APPROACHES TOWARDS ALKALOIDS BEARING ALPHA-
TERTIARY AMINES
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TARGETING A DYNAMIC PROTEIN–PROTEIN INTERACTION:
FRAGMENT SCREENING AGAINST THE MALARIA MYOSIN A MOTOR
COMPLEX